2018 Week 1 NFL Picks Against the Spread and Straight Up

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Deshaun Watson and the Houston Texans are 6.5-point underdogs against the New England Patriots. | Bob Levey/Getty Images

If you are anything like us at The Odds-On Favorite, then the last seven months without meaningful NFL football have likely been excruciatingly painful for you. Fortunately, the 2018 NFL season will officially be back when the Philadelphia Eagles host the Atlanta Falcons in the season opener on Thursday night.

With the NFL season now just hours away, here is a look at our Week 1 staff picks — both against the spread (ATS) and straight up — for all 16 games, and our picks for each game’s point totals (over/under).

Odds courtesy of Sportsbook.ag as of September 6, 2018

Atlanta Falcons vs. Philadelphia Eagles

  • Point Spread: Eagles favored by 1 points
  • Over/Under: 45
  • Money Line: 
    1. Falcons (-110)
    2. Eagles (-110)
  • Location: Lincoln Financial Field, Philadelphia, PA
ATS Picks:
  • Jason: Falcons (+1)
  • Jimmie: Falcons (+1)
S/U Picks:
  • Jason: Falcons
  • Jimmie: Falcons
O/U Picks:
  • Jason: Over
  • Jimmie: Over

Pittsburgh Steelers vs. Cleveland Browns

  • Point Spread: Steelers favored by 4 points
  • Over/Under: 44
  • Money Line: 
    1. Steelers (-200)
    2. Browns (+170)
  • Location: FirstEnergy Stadium, Cleveland, OH
ATS Picks:
  • Jason: Steelers (-4)
  • Jimmie: Steelers (-4)
S/U Picks:
  • Jason: Steelers
  • Jimmie: Steelers
O/U Picks:
  • Jason: Under
  • Jimmie: Over

San Francisco 49ers vs. Minnesota Vikings

  • Point Spread: Vikings favored by 6.5 points
  • Over/Under: 46
  • Money Line: 
    1. 49ers (+220)
    2. Vikings (-260)
  • Location: U.S. Bank Stadium, Minneapolis, MN
ATS Picks:
  • Jason: Vikings (-6.5)
  • Jimmie: Vikings (-6.5)
S/U Picks:
  • Jason: Vikings
  • Jimmie: Vikings
O/U Picks:
  • Jason: Over
  • Jimmie: Under

Cincinnati Bengals vs. Indianapolis Colts

  • Point Spread: Colts favored by 2.5 points
  • Over/Under: 48.5
  • Money Line: 
    1. Bengals (+125)
    2. Colts (-145)
  • Location: Lucas Oil Stadium, Indianapolis, IN
ATS Picks:
  • Jason: Colts (-2.5)
  • Jimmie: Colts (-2.5)
S/U Picks:
  • Jason: Colts
  • Jimmie: Colts
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Buffalo Bills vs. Baltimore Ravens

  • Point Spread: Ravens favored by 7 points
  • Over/Under: 40.5
  • Money Line: 
    1. Bills (+260)
    2. Ravens (-320)
  • Location: M&T Bank Stadium, Baltimore, MD
ATS Picks:
  • Jason: Ravens (-7)
  • Jimmie: Ravens (-7)
S/U Picks:
  • Jason: Ravens
  • Jimmie: Ravens
O/U Picks:
  • Jason: Under
  • Jimmie: Under

Jacksonville Jaguars vs. New York Giants

  • Point Spread: Jaguars favored by 3 points
  • Over/Under: 43.5
  • Money Line: 
    1. Jaguars (-165)
    2. Giants (+145)
  • Location: MetLife Stadium, East Rutherford, NJ
ATS Picks:
  • Jason: Jaguars (-3)
  • Jimmie: Giants (+3)
S/U Picks:
  • Jason: Jaguars
  • Jimmie: Jaguars
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Tampa Bay Buccaneers vs. New Orleans Saints

  • Point Spread: Saints favored by 9.5 points
  • Over/Under: 49.5
  • Money Line: 
    1. Buccaneers (+350)
    2. Saints (-440)
  • Location: Mercedes-Benz Superdome, New Orleans, LA
ATS Picks:
  • Jason: Saints (-9.5)
  • Jimmie: Saints (-9.5)
S/U Picks:
  • Jason: Saints
  • Jimmie: Saints
O/U Picks:
  • Jason: Under
  • Jimmie: Under

Houston Texans vs. New England Patriots

  • Point Spread: Patriots favored by 6.5 points
  • Over/Under: 51
  • Money Line: 
    1. Texans (+220)
    2. Patriots (-260)
  • Location: Gillette Stadium, Foxboro, MA
ATS Picks:
  • Jason: Patriots (-6.5)
  • Jimmie: Texans (+6.5)
S/U Picks:
  • Jason: Patriots
  • Jimmie: Patriots
O/U Picks:
  • Jason: Over
  • Jimmie: Over

Tennessee Titans vs. Miami Dolphins

  • Point Spread: Titans favored by 1.5 points
  • Over/Under: 45
  • Money Line: 
    1. Titans (-115)
    2. Dolphins (-105)
  • Location: Hard Rock Stadium, Miami Gardens, FL
ATS Picks:
  • Jason: Titans (-1.5)
  • Jimmie: Titans (-1.5)
S/U Picks:
  • Jason: Titans
  • Jimmie: Titans
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Kansas City Chiefs vs. Los Angeles Chargers

  • Point Spread: Chargers favored by 3.5 points
  • Over/Under: 48
  • Money Line: 
    1. Chiefs (+157)
    2. Chargers (-180)
  • Location: StubHub Center, Carson, CA
ATS Picks:
  • Jason: Chargers (-3.5)
  • Jimmie: Chargers (-3.5)
S/U Picks:
  • Jason: Chargers
  • Jimmie: Chargers
O/U Picks:
  • Jason: Over
  • Jimmie: Over

Seattle Seahawks vs. Denver Broncos

  • Point Spread: Broncos favored by 3 points
  • Over/Under: 42.5
  • Money Line: 
    1. Seahawks (+130)
    2. Broncos (-150)
  • Location: Broncos Stadium at Mile High, Denver, CO
ATS Picks:
  • Jason: Push
  • Jimmie: Broncos (-3)
S/U Picks:
  • Jason: Broncos
  • Jimmie: Broncos
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Dallas Cowboys vs. Carolina Panthers

  • Point Spread: Panthers favored by 3 points
  • Over/Under: 42.5
  • Money Line: 
    1. Cowboys (+130)
    2. Panthers (-150)
  • Location: Bank of America Stadium, Charlotte, NC
ATS Picks:
  • Jason: Push
  • Jimmie: Panthers (-3)
S/U Picks:
  • Jason: Panthers
  • Jimmie: Panthers
O/U Picks:
  • Jason: Over
  • Jimmie: Over

Washington Redskins vs. Arizona Cardinals

  • Point Spread: Even
  • Over/Under: 44
  • Money Line: 
    1. Redskins (-110)
    2. Cardinals (-110)
  • Location: University of Phoenix Stadium, Glendale, AZ
ATS Picks:
  • Jason: Redskins
  • Jimmie: Cardinals
S/U Picks:
  • Jason: Redskins
  • Jimmie: Cardinals
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Chicago Bears vs. Green Bay Packers

  • Point Spread: Packers favored by 7.5 points
  • Over/Under: 48
  • Money Line: 
    1. Bears (+260)
    2. Packers (-320)
  • Location: Lambeau Field, Green Bay, WI
ATS Picks:
  • Jason: Packers (-7.5)
  • Jimmie: Packers (-7.5)
S/U Picks:
  • Jason: Packers
  • Jimmie: Packers
O/U Picks:
  • Jason: Under
  • Jimmie: Over

New York Jets vs. Detroit Lions

  • Point Spread: Lions favored by 6.5 points
  • Over/Under: 45
  • Money Line: 
    1. Jets (+230)
    2. Lions (-280)
  • Location: Ford Field, Detroit, MI
ATS Picks:
  • Jason: Jets (+6.5)
  • Jimmie: Lions (-6.5)
S/U Picks:
  • Jason: Lions
  • Jimmie: Lions
O/U Picks:
  • Jason: Under
  • Jimmie: Over

Los Angeles Rams vs. Oakland Raiders

  • Point Spread: Rams favored by 4.5 points
  • Over/Under: 49.5
  • Money Line: 
    1. Rams (-210)
    2. Raiders (+177)
  • Location: Oakland Coliseum, Oakland, CA
ATS Picks:
  • Jason: Rams (-4.5)
  • Jimmie: Rams (-4.5)
S/U Picks:
  • Jason: Rams
  • Jimmie: Rams
O/U Picks:
  • Jason: Under
  • Jimmie: Under

Follow Jimmie on Twitter: @jimmiekaylor.
Follow Jason on Twitter: @JasonAlsher.
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Posted in: NFL